Cheatwood Joseph L, Emerick April J, Kartje Gwendolyn L
Hines VA Hospital, Illinois, USA.
Top Stroke Rehabil. 2008 Jan-Feb;15(1):42-50. doi: 10.1310/tsr1501-42.
Ischemic stroke affects many new patients each year. The sequelae of brain ischemia can include lasting sensorimotor and cognitive deficits, which negatively impact quality of life. Currently, treatment options for improving poststroke deficits are limited, and the development of new clinical alternatives to improve functional recovery after stroke is actively under investigation. Anti-Nogo-A immunotherapy to reduce the central nervous system inhibitory environment, cell transplantation strategies, pharmacological agents, and movement-based therapies represent emerging treatments of poststroke deficits through enhancement of neuroanatomical plasticity.
每年有许多新患者遭受缺血性中风。脑缺血的后遗症可能包括持久的感觉运动和认知缺陷，这对生活质量产生负面影响。目前，改善中风后缺陷的治疗选择有限，开发新的临床替代方案以改善中风后的功能恢复正在积极研究中。通过增强神经解剖可塑性来减少中枢神经系统抑制环境的抗Nogo - A免疫疗法、细胞移植策略、药物制剂和基于运动的疗法代表了中风后缺陷的新兴治疗方法。
