Freeman I, Grunwald A M, Hoory S, Bodenheimer M M
Long Island Jewish Medical Center, Heart Institute, New Hyde Park, New York 11042.
J Nucl Med. 1991 Feb;32(2):292-8.
The timing effect of sestamibi administration with respect to the onset of myocardial ischemia and reperfusion was studied in swine. In different groups of animals sestamibi was administered prior to coronary artery occlusion, during occlusion, or 1/2 hour following reperfusion. Sestamibi administered prior to coronary occlusion resulted in an insignificant decrease in 99mTc activity in the ischemic zone. However, infarct zone activity was reduced to 62 +/- 14% of the nonischemic zone. In contrast, administration during coronary occlusion resulted in similar significant reductions of both ischemic and infarct zone activity. Administration of sestamibi during reperfusion resulted in normal ischemic zone activity and markedly reduced activity in the infarct zone. Significantly reduced activity in the infarct zone was found to be independent of the timing of sestamibi administration with respect to the onset of myocardial ischemia and/or reperfusion. Thus, cell viability appears required for uptake and retention of isotope activity.
在猪身上研究了心肌灌注显像剂司他米比给药时间对心肌缺血和再灌注开始的影响。在不同组的动物中，司他米比在冠状动脉闭塞前、闭塞期间或再灌注后半小时给药。冠状动脉闭塞前给药的司他米比导致缺血区99mTc活性无明显下降。然而，梗死区活性降至非缺血区的62±14%。相比之下，冠状动脉闭塞期间给药导致缺血区和梗死区活性均显著降低。再灌注期间给予司他米比导致缺血区活性正常，梗死区活性明显降低。发现梗死区活性显著降低与司他米比给药时间相对于心肌缺血和/或再灌注开始的时间无关。因此，细胞活力似乎是摄取和保留同位素活性所必需的。
