慢性口服美沙酮治疗对食蟹猴（猕猴属）孕期猴绒毛膜促性腺激素、雌二醇、硫酸脱氢表雄酮、孕酮、催乳素和皮质醇水平的影响。

The effect of chronic oral methadone treatment on monkey chorionic gonadotropin, estradiol, dehydroepiandrosterone sulfate, progesterone, prolactin and cortisol levels during pregnancy in the cynomolgus monkey (Macaca fascicularis).

作者信息

Hein P R, Schatorjé J S, Frencken H J, Segers M F, Thomas C M

机构信息

Department of Obstetrics and Gynecology, University Hospital Nijmegen, The Netherlands.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1991 Jan 30;38(2):145-50. doi: 10.1016/0028-2243(91)90192-n.

DOI:10.1016/0028-2243(91)90192-n

PMID:1825302

Abstract

The effect of chronic methadone treatment upon the serum levels of Estradiol (E2), Progesterone (P), Prolactin (Prl), monkey chorionic gonadotropin (mCG), dehydroepiandrosterone sulfate (DHEAS) and Cortisol (C) in pregnant Cynomolgus monkeys (Macaca fascicularis) is described in comparison with the hormone levels in a control group. Only DHEAS was significantly decreased in late pregnancy in the methadone group. From these data it can not be concluded that methadone treatment compromises (feto)placental function. The observed intra-uterine growth retardation in the methadone treated group might be a result of a direct influence of methadone upon growth.

摘要

与对照组的激素水平相比，描述了慢性美沙酮治疗对怀孕食蟹猴（猕猴）血清中雌二醇（E2）、孕酮（P）、催乳素（Prl）、猴绒毛膜促性腺激素（mCG）、硫酸脱氢表雄酮（DHEAS）和皮质醇（C）水平的影响。在美沙酮组中，仅在妊娠晚期DHEAS显著降低。从这些数据中不能得出美沙酮治疗会损害（胎儿）胎盘功能的结论。在美沙酮治疗组中观察到的宫内生长迟缓可能是美沙酮对生长直接影响的结果。