人绒毛膜促性腺激素和孕酮对食蟹猴子宫催乳素分泌的刺激作用。

Stimulation of uterine prolactin secretion by human chorionic gonadotropin and progesterone in the cynomolgus monkey.

作者信息

Ying Y K, Maier D B, Randolph J F, Kuslis S, Riddick D H

机构信息

Department of Obstetrics and Gynecology, Nassau County Medical Center, East Meadow, New York 11554.

出版信息

Fertil Steril. 1988 Dec;50(6):976-9. doi: 10.1016/s0015-0282(16)60383-7.

DOI:10.1016/s0015-0282(16)60383-7

PMID:3203763

Abstract

The ovulating cynomolgus monkey secretes immunoreactive prolactin (PRL) into the uterine cavity. Consistent with human endometrial explant data, uterine PRL is undetectable in the early secretory phase, then increases from the mid to late secretory phase, peaking premenstrually. The anovulatory monkey does not produce detectable uterine PRL. Human chorionic gonadotropin given repeatedly fails to induce PRL secretion in anovulatory monkeys but prolongs the luteal phase and thereby PRL secretion in ovulatory monkeys. Progesterone (P) induces PRL secretion in anovulatory monkeys after estrogen priming with a time delay of several days, indicating probable de novo synthesis. P appears to be an important stimulating factor in the control of uterine PRL secretion.

摘要

排卵的食蟹猴会向子宫腔内分泌免疫反应性催乳素（PRL）。与人类子宫内膜外植体数据一致，在分泌期早期子宫中无法检测到PRL，然后从分泌期中后期开始增加，在月经前达到峰值。无排卵的猴子不会产生可检测到的子宫PRL。反复给予人绒毛膜促性腺激素不能诱导无排卵猴子分泌PRL，但会延长黄体期，从而使排卵猴子分泌PRL。在雌激素预处理几天后，孕酮（P）可诱导无排卵猴子分泌PRL，这表明可能是从头合成。P似乎是控制子宫PRL分泌的一个重要刺激因素。