Balestrieri Maria Luisa, Fiorito Carmela, Crimi Ettore, Felice Francesca, Schiano Concetta, Milone Lara, Casamassimi Amelia, Giovane Alfonso, Grimaldi Vincenzo, del Giudice Vincenzo, Minucci Pellegrino Biagio, Mancini Francesco Paolo, Servillo Luigi, D'Armiento Francesco Paolo, Farzati Bartolomeo, Napoli Claudio
Int J Cardiol. 2008 May 23;126(2):295-7. doi: 10.1016/j.ijcard.2007.11.081. Epub 2008 Feb 5.
Circulating endothelial progenitor cells (EPCs) play a significant role in regeneration of damaged blood vessels. Levels and functional activities of EPCs are noticeable altered by risk factors for coronary heart disease (CHD) and compounds that can prevent or ameliorate EPC dysfunction are currently of special clinical interest. Here, we evaluate the effects of red wine (RW) on EPCs in C57BL/6J mice subjected to physical exercise. FACS computed counting showed a significant increase of EPC number (P<0.05) in mice after short-term supplementation with RW. VEGF serum concentration was significantly increased by physical training in the presence or absence of RW supplementation (P<0.001). These in vivo observations support previous in vitro observation of the beneficial effect of RW in the modulation of EPC levels.
循环内皮祖细胞（EPCs）在受损血管的再生中发挥着重要作用。冠心病（CHD）的危险因素会显著改变EPCs的水平和功能活性，目前能够预防或改善EPC功能障碍的化合物具有特殊的临床意义。在此，我们评估了红酒（RW）对进行体育锻炼的C57BL/6J小鼠体内EPCs的影响。流式细胞仪计数显示，短期补充RW后小鼠体内EPC数量显著增加（P<0.05）。无论是否补充RW，体育锻炼均显著提高了VEGF血清浓度（P<0.001）。这些体内观察结果支持了之前关于RW对EPC水平调节具有有益作用的体外观察。
