人鼻病毒的重组VP4在模型膜中诱导通透性。
Recombinant VP4 of human rhinovirus induces permeability in model membranes.
作者信息
Davis Matthew P, Bottley Graham, Beales Lucy P, Killington Richard A, Rowlands David J, Tuthill Tobias J
机构信息
Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom.
出版信息
J Virol. 2008 Apr;82(8):4169-74. doi: 10.1128/JVI.01070-07. Epub 2008 Feb 6.
Abstract
In common with all nonenveloped viruses, the mechanism of picornavirus membrane penetration during cell entry is poorly understood. The small, myristylated capsid protein VP4 has been implicated in this process. Here we show that recombinant VP4 of human rhinovirus 16 has the ability to associate with and induce membrane permeability in otherwise intact liposomes. This provides further evidence that VP4 plays a key role in picornavirus cell entry.
摘要
与所有无包膜病毒一样，人们对小核糖核酸病毒在细胞进入过程中穿透膜的机制了解甚少。小的、肉豆蔻酰化的衣壳蛋白VP4被认为参与了这一过程。在此我们表明，人鼻病毒16的重组VP4能够与原本完整的脂质体结合并诱导其膜通透性。这进一步证明了VP4在小核糖核酸病毒细胞进入过程中起关键作用。
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