Burgos Juan M, Begher Sandra, Silva Helder M Valadares, Bisio Margarita, Duffy Tomas, Levin Mariano J, Macedo Andrea M, Schijman Alejandro G
Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina.
Am J Trop Med Hyg. 2008 Feb;78(2):294-7.
Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, the patient's blood was infected by a mixture of T. cruzi I and T. cruzi IId/e polyclonal populations while the cerebrospinal fluid showed only a monoclonal T. cruzi I population. Our findings do not corroborate the original assumption of innocuity for T. cruzi I in the southern cone of the Americas and highlight lineage I tropism for central nervous system causing lethal Chagas reactivation.
从一名患有恰加斯病并伴有艾滋病且中枢神经系统严重受累的玻利维亚患者的外周血和脑脊液样本中，直接对克氏锥虫谱系、微卫星等位基因多态性和线粒体基因单倍型进行了分型。值得注意的是，该患者的血液感染了克氏锥虫I型和克氏锥虫IId/e多克隆群体的混合物，而脑脊液仅显示出单克隆的克氏锥虫I型群体。我们的研究结果并不支持美洲南锥体地区对克氏锥虫I型无害的最初假设，并突出了I型谱系对中枢神经系统的嗜性，可导致致命的恰加斯病再激活。
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