Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Division of Tropical Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Clin Microbiol Rev. 2024 Jun 13;37(2):e0009923. doi: 10.1128/cmr.00099-23. Epub 2024 Mar 28.
SUMMARYAs Chagas disease remains prevalent in the Americas, it is important that healthcare professionals and researchers are aware of the screening, diagnosis, monitoring, and treatment recommendations for the populations of patients they care for and study. Management of infection in immunocompromised hosts is challenging, particularly because, regardless of antitrypanosomal treatment status, immunocompromised patients with Chagas disease are at risk for reactivation, which can be lethal. Evidence-based practices to prevent and manage reactivation vary depending on the type of immunocompromise. Here, we review available data describing Chagas disease epidemiology, testing, and management practices for various populations of immunocompromised individuals, including people with HIV and patients undergoing solid organ and hematopoietic stem cell transplantation.
总结
由于恰加斯病在美洲仍然流行，因此医疗保健专业人员和研究人员了解他们所照顾和研究的患者群体的筛查、诊断、监测和治疗建议非常重要。免疫功能低下宿主感染的管理具有挑战性，特别是因为无论抗锥虫治疗状况如何，患有恰加斯病的免疫功能低下患者都有再激活的风险，这可能是致命的。预防和管理再激活的循证实践因免疫功能低下的类型而异。在这里，我们回顾了描述恰加斯病流行病学、各种免疫功能低下个体人群的检测和管理实践的现有数据，包括艾滋病毒感染者和接受实体器官和造血干细胞移植的患者。
