Simioli Federico, Sánchez-Cunto Milagro, Velázquez Elsa, Lloveras Susana, Orduna Tomás
Hospital de Enfermedades Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.
Instituto Nacional de Parasitología Dr. Mario Fatala Chaben, Buenos Aires, Argentina.
Rev Chilena Infectol. 2017 Feb;34(1):62-66. doi: 10.4067/S0716-10182017000100009.
Chagas disease (ChD), caused by the protozoan Trypanosoma cruzi, is an endemic anthropozoonosis in Latin America, linked to deficients socio-economic and cultural aspects and is considered one of the neglected tropical diseases. We report a fatal case of Chagas disease reactivation with central nervous system involvement in a patient with HIV infection, whose diagnosis was confirmed by positive PCR (polymerase chain reaction) test of blood, with treatment response efficiency with benznidazol and management and etiologic treatment was difficult due to limited number of antitrypanosomal drugs and the occurrence of frequent and serious adverse effects.
恰加斯病（ChD）由原生动物克氏锥虫引起，是拉丁美洲的一种地方性人畜共患病，与社会经济和文化方面的不足有关，被认为是被忽视的热带病之一。我们报告了一例恰加斯病再激活并累及中枢神经系统的致命病例，该患者为HIV感染者，血液聚合酶链反应（PCR）检测呈阳性确诊，使用苯硝唑治疗有反应，但由于抗锥虫药物数量有限且频繁出现严重不良反应，管理和病因治疗困难。
