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Th1和Th2淋巴细胞以及这些细胞产生的细胞因子在抗胆碱酯酶毒物亚急性中毒期间免疫反应抑制中的作用。

Role of Th1 and Th2 lymphocytes and cytokines produced by these cells in suppression of immune reactions during subacute poisoning with anticholinesterase toxicants.

作者信息

Zabrodskii P F, Germanchuk V G, Mandych V G, Kadushkin A M

机构信息

Saratov Military Institute of Radiation, Chemical, and Biological Protection.

出版信息

Bull Exp Biol Med. 2007 Jul;144(1):57-9. doi: 10.1007/s10517-007-0253-1.

DOI:10.1007/s10517-007-0253-1
PMID:18256752
Abstract

Experiments on Wistar rats showed that subacute poisoning with anticholinesterase toxicants zarin and agent VX (daily subcutaneous injections in 1/7 LD50 for 6 days) led to suppression of cellular and humoral immune reactions and to a decrease in blood concentrations of cytokines (IL-2, IL-4, IFN-gamma) with a reduction of the IFN-gamma/IL-4 and IL-2/IL-4 ratios, which attests to more pronounced decrease in Th1 lymphocyte function in comparison with Th2 cells.

摘要

对Wistar大鼠进行的实验表明，用抗胆碱酯酶毒物扎林和VX毒剂进行亚急性中毒（每天皮下注射1/7 LD50，持续6天）会导致细胞免疫和体液免疫反应受到抑制，细胞因子（IL-2、IL-4、IFN-γ）的血液浓度降低，IFN-γ/IL-4和IL-2/IL-4比值下降，这证明与Th2细胞相比，Th1淋巴细胞功能下降更为明显。

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