（+）-育亨宾的催化不对称全合成。
Catalytic asymmetric total synthesis of (+)-yohimbine.
作者信息
Mergott Dustin J, Zuend Stephan J, Jacobsen Eric N
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
Org Lett. 2008 Mar 6;10(5):745-8. doi: 10.1021/ol702781q. Epub 2008 Feb 8.
PMID:18257582
Abstract
The total synthesis of (+)-yohimbine was achieved in 11 steps and 14% overall yield. The absolute configuration was established through a highly enantioselective thiourea-catalyzed acyl-Pictet-Spengler reaction, and the remaining 4 stereocenters were set simultaneously in a substrate-controlled intramolecular Diels-Alder reaction.
摘要
（+）-育亨宾的全合成以11步反应完成，总产率为14%。其绝对构型通过高度对映选择性的硫脲催化酰基-Pictet-Spengler反应确定，其余4个立体中心在底物控制的分子内Diels-Alder反应中同时构建。
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