育亨宾的多面性——是有前景的治疗潜力还是风险？

Multifaced Nature of Yohimbine-A Promising Therapeutic Potential or a Risk?

作者信息

Nowacka Agnieszka, Śniegocka Martyna, Śniegocki Maciej, Ziółkowska Ewa, Bożiłow Dominika, Smuczyński Wojciech

机构信息

Department of Neurosurgery, Nicolas Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, ul. Curie Skłodowskiej 9, 85-094 Bydgoszcz, Poland.

Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161 Rome, Italy.

出版信息

Int J Mol Sci. 2024 Nov 29;25(23):12856. doi: 10.3390/ijms252312856.

DOI:10.3390/ijms252312856

PMID:39684567

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11641166/

Abstract

A natural compound derived from the Pausinystalia yohimbe tree-yohimbine, has a rich history of use in traditional medicine and is currently being explored for its potential therapeutic applications. This indole alkaloid primarily acts as an antagonist of α2-adrenergic receptors. Initially recognized for its purported aphrodisiac properties, yohimbine has been investigated for a wide range of applications, including sports or the treatment of erectile dysfunction and metabolic disorders. However, toxicological concerns exist, particularly at higher doses. Ongoing researches help to fully assess yohimbine's efficacy and safety profile and to explore strategies for enhancing its bioavailability and reducing toxicity. This review examines the multifaceted nature of yohimbine, delving into both its promising therapeutic potential and the associated risks.

摘要

一种从育亨宾树中提取的天然化合物——育亨宾，在传统医学中有着悠久的使用历史，目前人们正在探索其潜在的治疗应用。这种吲哚生物碱主要作为α2肾上腺素能受体的拮抗剂发挥作用。育亨宾最初因其所谓的壮阳特性而闻名，目前已针对广泛的应用进行了研究，包括体育运动、勃起功能障碍治疗和代谢紊乱治疗。然而，存在毒理学方面的担忧，尤其是在高剂量时。正在进行的研究有助于全面评估育亨宾的疗效和安全性，并探索提高其生物利用度和降低毒性的策略。这篇综述探讨了育亨宾的多面性，深入研究了其有前景的治疗潜力和相关风险。