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Crystallographic analysis of the intact metal centres [3Fe-4S](1+/0) and [4Fe-4S](2+/1+) in a Zn(2+) -containing ferredoxin.

作者信息

Frazão Carlos, Aragão David, Coelho Ricardo, Leal Sónia S, Gomes Cláudio M, Teixeira Miguel, Carrondo Maria Arménia

机构信息

Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av da República, Oeiras, Portugal.

出版信息

FEBS Lett. 2008 Mar 5;582(5):763-7. doi: 10.1016/j.febslet.2008.01.041. Epub 2008 Feb 5.

DOI:10.1016/j.febslet.2008.01.041
PMID:18258200
Abstract

Detailed structural models of di-cluster seven-iron ferredoxins constitute a valuable resource for folding and stability studies relating the metal cofactors' role in protein stability. The here reported, hemihedric twinned crystal structure at 2.0 A resolution from Acidianus ambivalens ferredoxin, shows an integral 103 residues, physiologically relevant native form composed by a N-terminal extension comprising a His/Asp Zn(2+) site and the ferredoxin (betaalphabeta)(2) core, which harbours intact clusters I and II, a 3Fe-4S and a 4Fe-4S centres. This is in contrast with the previously available ferredoxin structure from Sulfolofus tokodai, which was obtained from an artificial oxidative conversion with two 3Fe-4S centres and poor definition around cluster II.

摘要

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