Bahner U, Geiger H, Palkovits M, Ganten D, Klotz B, Heidland A
Medical Clinic of the University, Division of Nephrology, Würzburg, Federal Republic of Germany.
Kidney Int. 1991 Jan;39(1):33-8. doi: 10.1038/ki.1991.4.
The central atrial natriuretic peptides (ANF)-system was investigated in volume-dependent, one-kidney, one-clip (1K1C) and renin-dependent two-kidney, one-clip (2K1C) renovascular hypertensive rats by radioimmunological measurement of ANF concentration in 18 selected brain areas. Significant changes were found in nine brain areas of 1K1C and in eight brain areas of 2K1C hypertensive rats. Except undirectional changes in the organum vasculosum laminae terminalis and the supraoptic nucleus, ANF concentration was changed in the opposite direction in all other brain areas, with an activation of the central ANF system in 1K1C and an inhibition in 2K1C hypertension. The localization of the alterations (circumventricular organs, anteroventral third ventricle region, hypothalamo hypophyseal system, brain stem) implies major differences in the central regulation of blood pressure and electrolyte and fluid homeostasis between these two models. The activation of the central ANF system in 1K1C hypertension may be a compensatory mechanism to prevent further increments in blood pressure and plasma volume. In contrast, the depression of the central ANF system in 2K1C hypertension may promote the elevation of the blood pressure.
通过放射免疫法测定18个选定脑区的心房钠尿肽（ANF）浓度，对容量依赖性的单肾单夹（1K1C）和肾素依赖性的双肾单夹（2K1C）肾血管性高血压大鼠的中枢ANF系统进行了研究。在1K1C高血压大鼠的9个脑区和2K1C高血压大鼠的8个脑区发现了显著变化。除终板血管器和视上核的变化无方向性外，所有其他脑区的ANF浓度均呈相反方向变化，1K1C高血压时中枢ANF系统激活，2K1C高血压时中枢ANF系统受抑制。这些变化的定位（室周器官、前腹侧第三脑室区域、下丘脑 - 垂体系统、脑干）表明这两种模型在血压以及电解质和液体稳态的中枢调节方面存在重大差异。1K1C高血压时中枢ANF系统的激活可能是一种防止血压和血浆容量进一步升高的代偿机制。相反，2K1C高血压时中枢ANF系统的抑制可能会促进血压升高。
