Suzuki K, Nogimura H, Wada H, Tomii M, Sugimura H, Horiguchi T, Kimura T, Harada Y
1st Dept. of Surgery, Hamamatsu University School of Medicine, Japan.
Gan To Kagaku Ryoho. 1991 Mar;18(3):431-5.
The effect of short-term (10 days) Medroxyprogesterone acetate (MPA) administration on side reactions of combination chemotherapy with ADR, VDS and CDDP for primary lung cancer was studied by comparisons of MPA administration group (20 cases) with non administration group (30 cases). 1) Frequency of vomiting, duration of nausea and body weight loss were significantly improved in MPA administration Group (p less than 0.01). 2) Leukocyte and neutrophil counts in MPA administration group especially 7-10 days after of chemotherapy were maintained higher than these of non administration group (p less than 0.05). 3) Major side effects including thromboembolism in MPA administration group had not been observed. These results indicated that short-term MPA administration was relatively safe and effective in combination chemotherapy including CDDP.
通过比较醋酸甲羟孕酮（MPA）给药组（20例）和非给药组（30例），研究了短期（10天）给予醋酸甲羟孕酮对阿霉素、长春地辛和顺铂联合化疗治疗原发性肺癌副作用的影响。1）MPA给药组呕吐频率、恶心持续时间和体重减轻均有显著改善（p<0.01）。2）MPA给药组化疗后7-10天白细胞和中性粒细胞计数维持高于非给药组（p<0.05）。3）未观察到MPA给药组包括血栓栓塞在内的主要副作用。这些结果表明，短期给予MPA在含顺铂的联合化疗中相对安全有效。
