Romeis Jörg, Bartsch Detlef, Bigler Franz, Candolfi Marco P, Gielkens Marco M C, Hartley Susan E, Hellmich Richard L, Huesing Joseph E, Jepson Paul C, Layton Raymond, Quemada Hector, Raybould Alan, Rose Robyn I, Schiemann Joachim, Sears Mark K, Shelton Anthony M, Sweet Jeremy, Vaituzis Zigfridas, Wolt Jeffrey D
Agroscope Reckenholz-Tänikon Research Station ART, Reckenholzstr. 191, 8046 Zurich, Switzerland.
Nat Biotechnol. 2008 Feb;26(2):203-8. doi: 10.1038/nbt1381.
An international initiative is developing a scientifically rigorous approach to evaluate the potential risks to nontarget arthropods (NTAs) posed by insect-resistant, genetically modified (IRGM) crops. It adapts the tiered approach to risk assessment that is used internationally within regulatory toxicology and environmental sciences. The approach focuses on the formulation and testing of clearly stated risk hypotheses, making maximum use of available data and using formal decision guidelines to progress between testing stages (or tiers). It is intended to provide guidance to regulatory agencies that are currently developing their own NTA risk assessment guidelines for IRGM crops and to help harmonize regulatory requirements between different countries and different regions of the world.
一项国际倡议正在制定一种科学严谨的方法，以评估抗虫转基因作物对非靶标节肢动物（NTA）的潜在风险。该方法采用了在监管毒理学和环境科学领域国际通用的分层风险评估方法。该方法侧重于明确表述风险假设的制定和测试，充分利用现有数据，并使用正式的决策指南在测试阶段（或层级）之间推进。其目的是为目前正在制定自身抗虫转基因作物非靶标节肢动物风险评估指南的监管机构提供指导，并有助于协调世界不同国家和地区之间的监管要求。
