Park Seoung Ju, Lee Yong Chul
Department of Internal Medicine, Airway Remodeling Laboratory, Chonbuk National University Medical School, Jeonju, South Korea.
J Asthma. 2008 Jan-Feb;45(1):1-8. doi: 10.1080/02770900701247319.
Peroxisome proliferator-activated receptor gamma (PPARgamma) has been characterized as a regulator of adipocyte differentiation and lipid metabolism. However, in the last few years growing evidence indicates that PPARgamma plays an important role in controlling immune and inflammatory responses. Upregulation of PPARgamma expression is observed in asthmatic airways, and an involvement of PPARgamma in airway inflammation and airway hyperresponsiveness in asthma has been reported. Recent studies have demonstrated that PPARgamma ligands may have a therapeutic effect in asthma. This article reviews the latest knowledge and studies on the roles and mechanisms of PPARgamma and PPARgamma ligands in asthma.
过氧化物酶体增殖物激活受体γ（PPARγ）已被确认为脂肪细胞分化和脂质代谢的调节因子。然而，在过去几年中，越来越多的证据表明PPARγ在控制免疫和炎症反应中发挥着重要作用。在哮喘气道中观察到PPARγ表达上调，并且有报道称PPARγ参与哮喘中的气道炎症和气道高反应性。最近的研究表明，PPARγ配体可能对哮喘具有治疗作用。本文综述了关于PPARγ及其配体在哮喘中的作用和机制的最新知识与研究。
