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过氧化物酶体增殖物激活受体γ在炎症中的作用。食物成分的治疗干预前景。

Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components.

作者信息

Martin Harry

机构信息

The New Zealand Institute for Plant & Food Research Limited, Palmerston North, New Zealand.

出版信息

Mutat Res. 2009 Oct 2;669(1-2):1-7. doi: 10.1016/j.mrfmmm.2009.06.009. Epub 2009 Jun 27.

Abstract

Peroxisome proliferator activated receptor gamma (PPARgamma) is a ligand-dependent transcription factor and a member of the nuclear receptor superfamily. Acting as sensors of hormones, vitamins, endogenous metabolites and xenobiotic compounds, the nuclear receptors control the expression of a very large number of genes. PPARgamma has been known for some time to regulate adipocyte differentiation, fatty acid storage and glucose metabolism, and is a target of anti-diabetic drugs. More recently, PPARgamma has been recognized as playing a fundamentally important role in the immune response through its ability to inhibit the expression of inflammatory cytokines and to direct the differentiation of immune cells towards anti-inflammatory phenotypes. A feature of PPARgamma is the structural diversity of its ligands, which encompass endogenous metabolites, dietary compounds and synthetic drugs. The high and increasing incidence of inflammatory and allergic disease, coupled with encouraging results from recent clinical trials, suggest that natural PPARgamma agonists found in foods may be beneficial to human health by acting as anti-inflammatory molecules. PPARgamma is therefore not only a target of the pharmaceutical industry, but also of great potential interest to the food industry, since it is activated by several natural dietary constituents. The prospects for dietary intervention in inflammatory disease have improved somewhat over the last few years, and are reviewed here.

摘要

过氧化物酶体增殖物激活受体γ(PPARγ)是一种配体依赖性转录因子,属于核受体超家族成员。核受体作为激素、维生素、内源性代谢物和外源性化合物的传感器,控制着大量基因的表达。一段时间以来,人们已经知道PPARγ可调节脂肪细胞分化、脂肪酸储存和葡萄糖代谢,并且是抗糖尿病药物的作用靶点。最近,PPARγ通过抑制炎症细胞因子的表达以及引导免疫细胞向抗炎表型分化的能力,被认为在免疫反应中发挥着至关重要的作用。PPARγ的一个特点是其配体的结构多样性,这些配体包括内源性代谢物、膳食化合物和合成药物。炎症和过敏性疾病的高发病率及不断上升,再加上近期临床试验取得的令人鼓舞的结果,表明食物中发现的天然PPARγ激动剂可能作为抗炎分子对人类健康有益。因此,PPARγ不仅是制药行业的靶点,对食品行业也极具潜在意义,因为它可被几种天然膳食成分激活。在过去几年中,饮食干预炎症性疾病的前景有所改善,本文对此进行综述。

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