Grota L J
Dev Psychobiol. 1976 May;9(3):211-5. doi: 10.1002/dev.420090304.
Rats were handled for 3 min daily for 3 weeks before or after weaning or were left totally undisturbed. At 80 days of age, animals from each group were selected for corticosterone half-life determination. Adrenal tissue from thr remaining animals was incubated in vitro in the presence or absence of ACTH. Handled and unmanipulated animals did nto differ in half-life or in adrenocortical output. These data do not support the hypothesis that the reduced adrenocortical reactivity that results from manipulating animals is due to either the metabolsim of corticosterone or the response of the adrenal cortex to ACTH.
在断奶前或断奶后，每天对大鼠进行3分钟的处理，持续3周，或者完全不打扰它们。在80日龄时，从每组中挑选动物来测定皮质酮的半衰期。将其余动物的肾上腺组织在有或没有促肾上腺皮质激素（ACTH）的情况下进行体外培养。经过处理和未处理的动物在半衰期或肾上腺皮质输出方面没有差异。这些数据不支持这样的假设，即因处理动物而导致的肾上腺皮质反应性降低是由于皮质酮的代谢或肾上腺皮质对促肾上腺皮质激素的反应。
