Hartmann F, Jentzen F
Horm Metab Res. 1979 Feb;11(2):158-60. doi: 10.1055/s-0028-1092700.
Amphiphilic drugs like chlorphentermine induce a generalized lipid storage disease upon chronic application. The adrenal cortex is among the organs most heavily affected. We therefore determined the urinary corticosterone excretion during the treatment of rats with chlorphentermine and the corticosterone content of the adrenals and its blood level at the end of the treatment period. In addition, the responsiveness of adrenal cortex was tested by application of ACTH. During treatment, the corticosterone excretion declined considerably. Both the corticosterone content of the adrenals and the plasma level were found depressed at the end of a treatment period of 8 weeks. The ACTH evoked response was also diminished. The results indicate that the chlorphentermine-induced lipidosis is associated with a reduced corticosterone production of the adrenal cortex of rats. At present it cannot be decided whether the cortical insufficiency is causally related to lipidotic alterations of the cortical cells, or whether it is caused or additionally influenced by alteration at a higher level, e.g. hypothalamic centers or anterior pituitary.
像氯苯丁胺这样的两亲性药物长期应用会引发全身性脂质贮积病。肾上腺皮质是受影响最严重的器官之一。因此，我们测定了用氯苯丁胺治疗大鼠期间尿中皮质酮的排泄量，以及治疗期末肾上腺中皮质酮的含量及其血液水平。此外，通过应用促肾上腺皮质激素（ACTH）来测试肾上腺皮质的反应性。治疗期间，皮质酮排泄量大幅下降。在8周的治疗期末，发现肾上腺中皮质酮含量和血浆水平均降低。ACTH引发的反应也减弱。结果表明，氯苯丁胺诱导的脂质osis与大鼠肾上腺皮质皮质酮生成减少有关。目前尚无法确定皮质功能不全是否与皮质细胞的脂质变性有因果关系，或者它是否由更高水平的改变引起或受到额外影响，例如下丘脑中枢或垂体前叶。
