Einarsson Jon I, Audbergsson Bjarki O, Thorsteinsson Adalbjorn
Department of Obstetrics and Gynecology, Landspitali-University Hospital, Reykjavik, Iceland.
J Minim Invasive Gynecol. 2008 Jan-Feb;15(1):26-31. doi: 10.1016/j.jmig.2007.08.616.
We sought to estimate effectiveness of transdermal scopolamine to prevent postoperative nausea and vomiting after gynecologic laparoscopy.
Patients were randomized to receive preoperative transdermal scopolamine or placebo. Main outcome measure was incidence of nausea during the first 24 hours postoperatively. Wilcoxon rank sum, Student t, chi2, and Fischer exact tests were used for data analysis (Canadian Task Force classification IA).
Academic teaching hospital.
A total of 48 patients undergoing gynecologic laparoscopy were studied.
Randomized administration of transdermal Scopolamine or placebo in patients having gynecologic laparoscopic surgery.
Patients in the scopolamine group had significantly less incidence of nausea (20.8% vs 62.5%, p = .003) and vomiting (8.3% vs 37.5%, p = .016) during the first 24 hours after surgery. Number needed to treat was 3 (95% CI 1.5, 6.1) for nausea and 4 (95% CI 1.9, 14.6) for vomiting. Symptoms of visual disturbance and dry mouth were more common in the scopolamine group.
Scopolamine patch significantly reduces incidence and severity of nausea and vomiting in the first 24 hours after gynecologic laparoscopic surgery.
我们试图评估透皮东莨菪碱预防妇科腹腔镜术后恶心呕吐的有效性。
患者被随机分为术前接受透皮东莨菪碱或安慰剂组。主要结局指标为术后24小时内恶心的发生率。采用Wilcoxon秩和检验、Student t检验、卡方检验和Fisher精确检验进行数据分析（加拿大工作组分类IA）。
教学医院。
共研究了48例接受妇科腹腔镜手术的患者。
对接受妇科腹腔镜手术的患者随机给予透皮东莨菪碱或安慰剂。
东莨菪碱组患者术后24小时内恶心发生率（20.8%对62.5%，p = 0.003）和呕吐发生率（8.3%对37.5%，p = 0.016）显著较低。恶心的治疗所需人数为3（95%CI 1.5，6.1），呕吐的治疗所需人数为4（95%CI 1.9，14.6）。东莨菪碱组视觉障碍和口干症状更为常见。
东莨菪碱贴片显著降低妇科腹腔镜术后24小时内恶心和呕吐的发生率及严重程度。
