正常血脂和高血脂受试者近端小肠中胆汁酸吸收的证据。
Evidence for the absorption of bile acids in the proximal small intestine of normo- and hyperlipidaemic subjects.
作者信息
Angelin B, Einarsson K, Hellström K
出版信息
Gut. 1976 Jun;17(6):420-5. doi: 10.1136/gut.17.6.420.
Abstract
Bile acid composition was determined in duodenal and jejunal aspirates obtained under fasting conditions in normolipidaemic controls and in patients with the type IIa and type IV lipoprotein patterns. In 17 out of the 22 subjects studied, the duodenal as compared with the jejunal aspirates contained proportionally more CD (chenodeoxycholic acid) than C (cholic acid). The two types of aspirates also differed slightly with regard to the D (deoxycholic acid): CD ratio, which was higher in samples drawn from the jejunum. These findings, compatible with an absorpiton of about 30% of CD in the upper small intestine, were approximately the same in all groups of patients. As evidenced by additional experiments in two subjects, an oral intake of cream does not significantly influence the absorption of CD in the upper small intestine.
摘要
在正常血脂对照组以及具有IIa型和IV型脂蛋白模式的患者中，于空腹条件下获取十二指肠和空肠抽吸物，测定胆汁酸成分。在所研究的22名受试者中，有17名受试者的十二指肠抽吸物与空肠抽吸物相比，鹅去氧胆酸（CD）与胆酸（C）的比例相对更高。两种抽吸物在脱氧胆酸（D）与鹅去氧胆酸的比例方面也略有不同，空肠抽取的样本中该比例更高。这些结果与约30%的鹅去氧胆酸在小肠上段被吸收的情况相符，在所有患者组中大致相同。两名受试者的额外实验表明，口服奶油对小肠上段鹅去氧胆酸的吸收没有显著影响。
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