Kovalszki A, Schumaker G L, Klein A, Terrin N, White A C
Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Bone Marrow Transplant. 2008 Jun;41(11):965-9. doi: 10.1038/bmt.2008.15. Epub 2008 Feb 11.
We performed a retrospective analysis of muscle strength testing obtained following sibling or unrelated donor hematopoietic stem cell transplant (HSCT) between 1 January 1999 and 31 December 2003 in a cohort of 44 subjects at Tufts-New England Medical Center. Maximal inspiratory pressure (PI(max)) was <or=80% predicted in 52% of subjects and <or=60% predicted in 20% of subjects; maximal expiratory pressure (PE(max)) was <or=80% predicted in 88% of subjects and <or=60% predicted in 74% of subjects. Patients with a PI(max) <or=60% predicted spent significantly longer time in hospital following HSCT compared with subjects with PI(max) 60% predicted. Grip strength (n=32) was reduced to <or=80% predicted in 75% of subjects and <or=60% predicted in 47% of subjects following HSCT. Analysis of paired measurements obtained before and after HSCT in 20 of the 44 subjects (45%) showed significant reduction in both PI(max) and PE(max) between the two measures. Respiratory and skeletal muscle weakness is present in a significant percentage of subjects undergoing pulmonary function testing in the post-HSCT period, and may contribute to pulmonary morbidity in subjects with pulmonary complications of HSCT.
我们对1999年1月1日至2003年12月31日期间在塔夫茨新英格兰医疗中心接受同胞或非亲属供者造血干细胞移植（HSCT）的44名受试者进行了肌肉力量测试的回顾性分析。52%的受试者最大吸气压力（PI(max)）低于或等于预测值的80%，20%的受试者低于或等于预测值的60%；88%的受试者最大呼气压力（PE(max)）低于或等于预测值的80%，74%的受试者低于或等于预测值的60%。与PI(max)高于预测值60%的受试者相比，PI(max)低于或等于预测值60%的患者在HSCT后住院时间明显更长。握力（n = 32）在HSCT后，75%的受试者降至低于或等于预测值的80%，47%的受试者降至低于或等于预测值的60%。对44名受试者中的20名（45%）在HSCT前后进行的配对测量分析显示，两种测量之间PI(max)和PE(max)均显著降低。在HSCT后接受肺功能测试的受试者中，相当比例的人存在呼吸和骨骼肌无力，这可能导致HSCT肺部并发症患者出现肺部发病情况。
