Parekh Trisha M, Ramachandran Rekha, Kim Young-Il, Balas Nora, Landier Wendy, Hageman Lindsey, Ross Elizabeth, Bosworth Alysia, Te Hok Sreng, Wong F Lennie, Bhatia Ravi, Forman Stephen J, Armenian Saro H, Weisdorf Daniel J, Dransfield Mark, Bhatia Smita
Division of Pulmonary and Critical Care, University of Texas Dell Medical School, 1601 Trinity Street Building A, Austin, TX, 78712, USA.
University of Alabama at Birmingham, Birmingham, AL, USA.
BMC Pulm Med. 2025 Jul 12;25(1):338. doi: 10.1186/s12890-025-03793-9.
Whether socioeconomic status is associated with pulmonary conditions in BMT survivors is unknown. In this study, we used data from the BMT Survivor Study (BMTSS) to determine the association between low annual household income and adverse pulmonary conditions (asthma, chronic cough or dyspnea, dyspnea at rest, recurrent pneumonia, current oxygen use) and health status in a retrospective cohort of BMT survivors.
BMTSS includes individuals who received BMT between 1974 and 2014 and survived for ≥ 2y after BMT at one of three participating sites. BMT survivors completed the BMTSS survey, providing details on demographics (including annual household income) and chronic health conditions as diagnosed by their healthcare providers. We used logistic regression models to determine the odds of low annual household income (≤$49,999) associated with a post-BMT pulmonary condition in BMT survivors, adjusting for relevant clinical and sociodemographic variables.
Our analysis included 2,814 participants (median age 58y; 44% female; 75% non-Hispanic White). Compared to survivors with annual household income ≥$100,000, those with income ≤$49,999 had higher odds of pulmonary conditions (asthma: OR = 1.80, 95%CI = 1.04-3.12, chronic cough or dyspnea: OR = 1.96, 95%CI = 1.37-2.81, and recurrent pneumonia: OR = 1.90, 95%CI = 1.00-3.60. Low income was also associated with suboptimal health status (poor/fair/good: OR = 2.36, 95%CI = 1.84-3.01; reference: very good/excellent).
The association between low annual household income and post-BMT pulmonary compromise in BMT survivors presents a need to understand the individual and environmental causes for this association. Future research should evaluate interventions to prevent post-transplant pulmonary morbidity in the lower-income survivor population.
造血干细胞移植（BMT）幸存者的社会经济地位是否与肺部疾病相关尚不清楚。在本研究中，我们使用了BMT幸存者研究（BMTSS）的数据，以确定低家庭年收入与不良肺部疾病（哮喘、慢性咳嗽或呼吸困难、静息时呼吸困难、复发性肺炎、当前吸氧情况）之间的关联，以及在一组BMT幸存者回顾性队列中的健康状况。
BMTSS纳入了1974年至2014年间接受BMT并在三个参与研究地点之一的其中一个地点BMT后存活≥2年的个体。BMT幸存者完成了BMTSS调查，提供了人口统计学细节（包括家庭年收入）以及其医疗服务提供者诊断的慢性健康状况。我们使用逻辑回归模型来确定BMT幸存者中与BMT后肺部疾病相关的低家庭年收入（≤49,999美元）的比值比，并对相关临床和社会人口学变量进行调整。
我们的分析纳入了2814名参与者（中位年龄58岁；44%为女性；75%为非西班牙裔白人）。与家庭年收入≥100,000美元的幸存者相比，收入≤49,999美元的幸存者患肺部疾病的几率更高（哮喘：比值比=1.80，95%置信区间=1.04-3.12；慢性咳嗽或呼吸困难：比值比=1.96，95%置信区间=1.37-2.81；复发性肺炎：比值比=1.90，95%置信区间=1.00-3.60）。低收入还与健康状况不佳相关（差/一般/良好：比值比=2.36，95%置信区间=1.84-3.01；对照：非常好/优秀）。
BMT幸存者中低家庭年收入与BMT后肺部损害之间的关联表明有必要了解这种关联的个体和环境原因。未来的研究应评估针对低收入幸存者群体预防移植后肺部发病的干预措施。
