Hamed H, Caleffi M, Fentiman I S, Thomas B, Bulbrook R D
ICRF Clinical Oncology Unit, Guy's Hospital, London, U.K.
Eur J Cancer. 1991;27(1):42-4. doi: 10.1016/0277-5379(91)90057-k.
Postoperative levels of steroid hormones have been measured in lymph and blood of 28 patients undergoing iridium implants as part of conservative treatment for operable breast cancer. The aim was to establish whether there were higher levels of hormones in lymph draining from necrosing tumour cells compared with peripheral blood levels. No differences were found in the ratios of estradiol, dehydroxyepiandrosterone sulphate or sex hormone-binding globulin in those patients with complete compared with incomplete excision of the primary tumour. However, premenopausal patients who had an incompletely excised primary tumour had increased levels of free testosterone in lymph draining from the tumour site on the third and fourth postoperative days. Thus androgens may have an important role in the intracellular metabolism of some breast cancers.
对28例接受铱植入术的患者进行了研究，这些患者将该手术作为可手术乳腺癌保守治疗的一部分，术后测量了其淋巴液和血液中的类固醇激素水平。目的是确定与外周血水平相比，坏死肿瘤细胞引流的淋巴液中激素水平是否更高。在原发肿瘤完全切除与未完全切除的患者中，雌二醇、硫酸脱氢表雄酮或性激素结合球蛋白的比率没有差异。然而，原发肿瘤未完全切除的绝经前患者在术后第三天和第四天，肿瘤部位引流的淋巴液中游离睾酮水平升高。因此，雄激素可能在某些乳腺癌的细胞内代谢中起重要作用。
