Cho H K, Kozu H, Peyman G A, Parry G J, Khoobehi B
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112.
Ophthalmic Surg. 1991 Jan;22(1):44-7.
The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.
在链脲佐菌素诱导的糖尿病大鼠中研究了盐酸氨基胍（AG）对血视网膜屏障的作用。一半大鼠给予AG（100mg/kg/天），其余大鼠不接受治疗。在注射链脲佐菌素前及诱导糖尿病2周后，对所有大鼠进行玻璃体荧光光度测定。注射链脲佐菌素2周后，未治疗组染料注射后60分钟玻璃体荧光素平均浓度的增加幅度大于AG治疗组，提示AG可能对血视网膜屏障的破坏有一定有益作用。
