Schwarzberg H, Roth N, Hiller K
Institute of Physiology, Medical Academy, Magdeburg, FRG.
Homeost Health Dis. 1991;33(5-6):251-5.
Effect of perinatal dex Rats received a single subcutaneous injection of 1 mg/kg dexamethasone at the age of seven days. One hundred days after the treatment, conditioned taste aversion was determined in the adult animals. Perinatally applied dexamethasone did not affect water consumption but caused a significant attenuation of conditioned taste aversion. These findings may be explained by dexamethasone effects upon brain development which cause impairment of memory functions or, alternatively, decreased responsiveness to aversive stimuli.
围产期给予地塞米松对大鼠的影响 大鼠在7日龄时接受一次皮下注射1mg/kg地塞米松。治疗100天后，测定成年动物的条件性味觉厌恶。围产期应用地塞米松不影响水的消耗，但导致条件性味觉厌恶显著减弱。这些发现可能用地塞米松对大脑发育的影响来解释，其导致记忆功能受损，或者对厌恶刺激的反应性降低。
