Svirtlih Neda, Jevtovic Djordje, Simonovic Jasmina, Delic Dragan, Dokic Ljubisa, Gvozdenovic Eleonora, Boricic Ivan, Nesic Zorica, Neskovic Gorana, Urban Vladimir
Institute for Infectious and Tropical Diseases, Clinical Centre of Serbia, Medical Faculty, University of Belgrade, Serbia.
Hepatogastroenterology. 2007 Dec;54(80):2324-7.
BACKGROUND/AIMS: Progression of chronic hepatitis C depends on the host and viral characteristics, duration of infection, co-infection with other viruses, etc. In this study, some of demographic, epidemiological and viral data as risk factors for a degree of liver fibrosis were evaluated.
A total of 144 patients was investigated (89 males, ages from 16-65 years) classified into two groups, with fibrosis scores 0-3 and 4-6, using the Ishak scoring system. Significant variables were entered into univariate logistic regression model and further multivariate analysis was performed.
There were 64% and 36% of patients with fibrosis scores 0-3 and 4-6, respectively. Gender, moderate to heavy alcohol abuse and high viral RNA were equally distributed between both groups. In univariate analysis, the age older than 40, history of intravenous drug abuse, and the genotype 1b were independently associated with different fibrosis scores. Multivariate regression analysis revealed ages older than 40 as the positive (p < 0.001), and younger than 40 as the negative predictive factors for fibrosis scores 4-6 and 0-3 (p < 0.001), respectively.
Our results indicate the age over 40 at the time of liver biopsy as the important risk factor for advanced liver disease in chronic hepatitis C according to fibrosis scores.
背景/目的：慢性丙型肝炎的进展取决于宿主和病毒特征、感染持续时间、与其他病毒的合并感染等。在本研究中，评估了一些人口统计学、流行病学和病毒学数据作为肝纤维化程度的危险因素。
共调查了144例患者（89例男性，年龄16 - 65岁），使用Ishak评分系统分为两组，纤维化评分为0 - 3和4 - 6。将显著变量纳入单因素逻辑回归模型并进行进一步的多因素分析。
纤维化评分为0 - 3和4 - 6的患者分别占64%和36%。性别、中度至重度酒精滥用和高病毒RNA在两组间分布均衡。在单因素分析中，年龄大于40岁、静脉注射吸毒史和基因1b型与不同的纤维化评分独立相关。多因素回归分析显示，年龄大于40岁是纤维化评分为4 - 6的阳性预测因素（p < 0.001），年龄小于40岁是纤维化评分为0 - 3的阴性预测因素（p < 0.001）。
我们的结果表明，根据纤维化评分，肝活检时年龄超过40岁是慢性丙型肝炎晚期肝病的重要危险因素。
