Pratschke Johann, Weiss Sascha, Neuhaus Peter, Pascher Andreas
Department of General, Visceral and Transplantation Surgery, Universitätsmedizin Berlin, Berlin, Germany.
Transpl Int. 2008 Jun;21(6):512-22. doi: 10.1111/j.1432-2277.2008.00643.x. Epub 2008 Feb 7.
Various factors determine the graft- and patient survival after transplantation. HLA-matching and immunological factors are of importance for the short- and long-term survival. Apart from these obvious determinants, nonimmunological factors play an important role in defining the baseline organ quality as well as the recipients' status. The influence of these parameters on graft- and patient survival is still underestimated and is a topic of debate. On account of the increasing acceptance of marginal-donor organs these events are of increasing importance for graft survival and long-term function. We review nonimmunological causes for deteriorated graft function and graft loss after solid organ transplantation.
多种因素决定移植后的移植物存活和患者存活。HLA配型和免疫因素对短期和长期存活至关重要。除了这些明显的决定因素外，非免疫因素在确定基线器官质量以及受者状态方面也起着重要作用。这些参数对移植物和患者存活的影响仍被低估，是一个有争议的话题。鉴于对边缘供体器官的接受度不断提高，这些情况对移植物存活和长期功能越来越重要。我们综述了实体器官移植后移植物功能恶化和移植物丢失的非免疫原因。
