Jibiki I, Fujimoto K, Kubota T, Yamaguchi N
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Pharmacol Biochem Behav. 1991 Jan;38(1):163-8. doi: 10.1016/0091-3057(91)90605-2.
We investigated effects of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on potentiation of field potentials elicited in the dentate gyrus by single shocks to the perforant path after kindling to the pathway in acutely prepared rabbits. MK-801, which was intracortically injected after the establishment of kindling-induced potentiation, remarkably and dose-dependently reduced the potentiation. These results suggest that activated NMDA receptors contribute substantially to the expression of kindling-induced potentiation.
我们研究了非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801对急性制备的家兔海马穿通通路点燃后，由穿通通路单次电刺激诱发的齿状回场电位增强的影响。在点燃诱导的增强效应建立后皮质内注射MK-801，其显著且剂量依赖性地降低了这种增强效应。这些结果表明，激活的NMDA受体对点燃诱导的增强效应的表达起重要作用。
