Nersesyan A K
Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.
Tsitol Genet. 2007 Sep-Oct;41(5):64-6.
Recent literature data are presented concerning micronuclei (MN) frequency in exfoliated cells of cervix cancer patients. These data strongly support a positive correlation between the MN level and malignization (changes from premalignant stage to cancer). It is suggested that the evaluation of frequency of MN in exfoliated cervical cells may be an additional criterion for establishing cervical cancer risk and the study of MN in cervix smears will increase the sensitivity and specificity of cytology which could impact in diagnostics and secondary prevention of cervical cancer.
本文呈现了有关宫颈癌患者脱落细胞中微核（MN）频率的近期文献数据。这些数据有力地支持了微核水平与恶性化（从癌前阶段转变为癌症）之间的正相关关系。有人提出，评估宫颈脱落细胞中的微核频率可能是确定宫颈癌风险的一项附加标准，并且对宫颈涂片进行微核研究将提高细胞学检查的敏感性和特异性，这可能会对宫颈癌的诊断和二级预防产生影响。
