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多囊卵巢综合征女性淋巴细胞和宫颈细胞中的微核频率。

Micronuclei frequencies in lymphocytes and cervical cells of women with polycystic ovarian syndrome.

作者信息

Karataylı Rengin, Gül Zamani Ayşe, Gezginç Kazım, Tuncez Ebru, Soysal Sema, Karanfil Fikriye, Acar Aynur, Yıldırım M Selman

机构信息

Konya Private Selçuklu Hospital, Clinic of Obstetrics and Gynecology, Konya, Turkey.

Necmettin Erbakan University Meram Faculty of Medicine, Department of Medical Genetics, Konya, Turkey.

出版信息

Turk J Obstet Gynecol. 2017 Sep;14(3):151-155. doi: 10.4274/tjod.10734. Epub 2017 Sep 30.

DOI:10.4274/tjod.10734
PMID:29085703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5651888/
Abstract

OBJECTIVE

The aim of this study was to determine micronucleus (MN) frequencies in exfoliated cervical cells and peripheral blood lymphocytes of women with polycystic ovarian syndrome (PCOS).

MATERIALS AND METHODS

Fifteen patients with PCOS and 11 healthy control patients were included in the study. Cervical smears and peripheral blood were collected from all patients. Specimens were analyzed for MN frequencies and compared between the groups. In addition to MN, other nuclear anomalies connected with both genotoxicity and cytotoxicity were evaluated.

RESULTS

The MN frequencies in cervical smear and peripheral blood lymphocytes were compared in patients with PCOS and normal controls. There was no statistically significant difference between the groups regarding micronucleus frequency in peripheral blood lymphocytes (p=0.239). The mean MN scores in exfoliated cervical cells of patients with PCOS and normal controls were 1.19±0.57 and 0.74±0.34, respectively. The difference regarding micronucleus frequencies in cervical cells was statistically significant between the groups (p=0.032).

CONCLUSION

Although study group is small, our study results support that there is an increased micronucleus frequency in cervical exfoliated cells of PCOS patients; this is a determinant of genetic hazard in the disease.

摘要

目的

本研究旨在确定多囊卵巢综合征（PCOS）女性宫颈脱落细胞和外周血淋巴细胞中的微核（MN）频率。

材料与方法

本研究纳入了15例PCOS患者和11例健康对照患者。采集所有患者的宫颈涂片和外周血。对标本进行微核频率分析并在组间进行比较。除微核外，还评估了与遗传毒性和细胞毒性相关的其他核异常。

结果

比较了PCOS患者和正常对照者宫颈涂片和外周血淋巴细胞中的微核频率。两组在外周血淋巴细胞微核频率方面无统计学显著差异（p = 0.239）。PCOS患者和正常对照者宫颈脱落细胞中的平均微核评分分别为1.19±0.57和0.74±0.34。两组在宫颈细胞微核频率方面的差异具有统计学意义（p = 0.032）。

结论

尽管研究组规模较小，但我们的研究结果支持PCOS患者宫颈脱落细胞中的微核频率增加；这是该疾病遗传风险的一个决定因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab25/5651888/39689040207f/TJOD-14-151-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab25/5651888/39689040207f/TJOD-14-151-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab25/5651888/39689040207f/TJOD-14-151-g3.jpg

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Micronucleus frequency in lymphocytes and 8-hydroxydeoxyguanosine level in plasma of women with polycystic ovary syndrome.多囊卵巢综合征妇女外周血淋巴细胞微核率与血浆 8-羟基脱氧鸟苷水平
Gynecol Endocrinol. 2010 Aug;26(8):590-5. doi: 10.3109/09513591003632142.
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Genome instability is increased in lymphocytes of women with polycystic ovary syndrome and is correlated with insulin resistance.多囊卵巢综合征女性淋巴细胞中的基因组不稳定性增加，且与胰岛素抵抗相关。
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