Porcile A, Gallardo E
School of Medicine, University of Chile, Hospital del Salvador, Santiago.
Fertil Steril. 1991 May;55(5):877-81. doi: 10.1016/s0015-0282(16)54291-5.
Effectiveness of 2-year treatment of hirsutism with low estrogen oral contraceptives (OCs) containing nonandrogenic or antiandrogenic progestogen. Evaluation of changes in plasma lipids.
Ten patients treated with desogestrel 150 micrograms + 30 micrograms ethinyl estradiol, 6 with desogestrel 150 micrograms + 50 micrograms ethinyl estradiol, 10 with cyproterone acetate 2 mg + 35 micrograms ethinyl estradiol. Random allocation. Paired comparisons.
19 normal women, not treated.
Academic tertiary care.
Women with hirsutism (idiopathic and/or polycystic ovary), 24 of 26 completed treatment.
Two-year treatment.
Hirsutism score, plasma testosterone, and lipids.
Initial hirsutism scores (11.8 +/- 0.6 SE) declined with treatment (-7.2 +/- 0.4, P less than 0.01) to 4.7 +/- 0.6, almost reaching control (3.6 +/- 0.3). Initial plasma cholesterol (4.33 mmol/L +/- 0.30 SE), similar to control (4.78 +/- 0.24), increased slowly over 2 years (+2.04 +/- 0.34, P less than 0.01). High-density lipoproteins cholesterol (1.05 mmol/L +/- 0.04 SE), similar to control (1.12 +/- 0.07), did not change the 1st year and increased at 2 years (+0.57 +/- 0.11, P less than 0.01). No differences appeared among treatment groups.
Treatment is very effective, 2 years for best results. The OCs tested are equally efficacious. Changes in plasma lipids are of some concern but of difficult interpretation.
评估含非雄激素或抗雄激素孕激素的低雌激素口服避孕药（OCs）治疗多毛症2年的有效性。评估血浆脂质的变化。
10例患者接受含150微克去氧孕烯 + 30微克炔雌醇的口服避孕药治疗，6例接受含150微克去氧孕烯 + 50微克炔雌醇的口服避孕药治疗，10例接受含2毫克醋酸环丙孕酮 + 35微克炔雌醇的口服避孕药治疗。随机分组。配对比较。
19名未接受治疗的正常女性。
学术性三级医疗机构。
多毛症女性（特发性和/或多囊卵巢），26例中有24例完成治疗。
为期2年的治疗。
多毛症评分、血浆睾酮和脂质。
初始多毛症评分（11.8 ± 0.6标准误）在治疗后下降（-7.2 ± 0.4，P < 0.01）至4.7 ± 0.6，几乎达到对照组水平（3.6 ± 0.3）。初始血浆胆固醇（4.33毫摩尔/升 ± 0.30标准误）与对照组（4.78 ± 0.24）相似，在2年中缓慢升高（+2.04 ± 0.34，P < 0.01）。高密度脂蛋白胆固醇（1.05毫摩尔/升 ± 0.04标准误）与对照组（1.12 ± 0.07）相似，第1年未变化，第2年升高（+0.57 ± 0.11，P < 0.01）。各治疗组之间未出现差异。
治疗非常有效，2年效果最佳。所测试的口服避孕药疗效相当。血浆脂质的变化值得关注，但难以解释。
