Shoenfeld Yehuda, Gershwin M Eric
Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel-Aviv University, Tel-Hashomer, 52621, Israel.
Clin Rev Allergy Immunol. 2008 Feb;34(1):1-3. doi: 10.1007/s12016-007-8014-5.
The most difficult component to understand in autoimmune disease has been the issue of causation. In contrast, there have been enormous gains in improved diagnostics as well as improved therapy. Indeed, the use of biologics have changed the profile of numerous autoimmune diseases. In this issue, we discuss two such aspects. Firstly, we place in perspective the use of anti-citrullinated protein antibodies in rheumatoid arthritis. Second, we discuss the increasing use of B cell depletion in the treatment of autoimmunity. Clinical Reviews in Allergy and Immunology is a unique venue for these themes because it covers the spectrum of allergy through autoimmunity. Indeed, we also present a special paper on the relationships of the hepatitis B virus and autoimmunity. Although the Th1 to Th2 dichotomy is well known to both murine and human immunologists, it is really in the study of specific inflammatory responses that they are correctly placed in the perspective of the continuum of immunopathology.
在自身免疫性疾病中，最难理解的部分一直是病因问题。相比之下，在诊断和治疗方面已经取得了巨大进展。事实上，生物制剂的使用已经改变了许多自身免疫性疾病的状况。在本期中，我们将讨论两个这样的方面。首先，我们将探讨抗瓜氨酸化蛋白抗体在类风湿性关节炎中的应用。其次，我们将讨论在自身免疫性疾病治疗中B细胞耗竭疗法的日益广泛使用。《过敏与免疫临床评论》是探讨这些主题的独特平台，因为它涵盖了从过敏到自身免疫性疾病的各个领域。事实上，我们还发表了一篇关于乙型肝炎病毒与自身免疫性关系的专题论文。尽管Th1与Th2二分法为鼠类和人类免疫学家所熟知，但只有在对特定炎症反应的研究中，它们才能在免疫病理学连续统一体的视角中得到正确定位。
