van Venrooij Walther J, Zendman Albert J W
Department of Biomolecular Chemistry, Radboud University Nijmegen, Nijmegen, The Netherlands.
Clin Rev Allergy Immunol. 2008 Feb;34(1):36-9. doi: 10.1007/s12016-007-8029-y.
The literature of the last 4 years confirms that the anti-CCP2 test is a very useful marker for the early and specific diagnosis of rheumatoid arthritis (RA). The anti-CCP2 test is very specific for RA (95-99%) and has sensitivity comparable to that of the rheumatoid factor (70-75%). The antibodies can be detected very early in the disease and can be used as an indicator for the progression and prognosis of RA. In this review, these interesting properties and some future possibilities of this diagnostic test are discussed.
过去4年的文献证实，抗环瓜氨酸肽2（anti-CCP2）检测是类风湿关节炎（RA）早期特异性诊断的一项非常有用的标志物。抗CCP2检测对RA具有高度特异性（95-99%），其敏感性与类风湿因子相当（70-75%）。这些抗体在疾病早期即可检测到，并可作为RA病情进展和预后的指标。在本综述中，将讨论这项诊断检测的这些有趣特性以及一些未来的可能性。
