Guo Linlang, Guo Ying, Xiao Sha
Department of Pathology, Zhujiang Hospital, NanFang Medical University, Guangzhou, China.
J Surg Oncol. 2008 Apr 1;97(5):428-32. doi: 10.1002/jso.20983.
Epithelial and endothelial tyrosine kinase (Etk), also known as bone marrow X kinase (Bmx) plays an important role in the growth, differentiation, apoptosis, proliferation, and tumorigenicity of epithelial cells. The purpose of this study was to investigate the expression of Etk/Bmx in intrahepatic cholangiocarcinoma (ICC) and correlated the expression with clinicopathological parameters.
Fifty-seven cases of ICC were immunostained for Etk/Bmx, HCV NS(5), PCNA, bcl-2, and NF-kappa B p65.
Etk/Bmx expression was present in 19 (33.3%) of 57 ICC specimens and correlated with cell differentiation and survival rate but not closely with tumor size and lymph node metastasis. There was a significant difference of expression of either PCNA-LI or Bcl-2 between Etk/Bmx-positive and -negative cases (P < 0.05). However, no statistically significant association was found between Etk/Bmx expression and presence of HCV-NS5 or NF-kappa B p65.
Our results indicate that Etk/Bmx may be involved in the development of ICC and be a predictor of poor prognosis for ICC. HCV infection and NF-kappa B appears unrelated to Etk/Bmx expression.
上皮和内皮酪氨酸激酶（Etk），也称为骨髓X激酶（Bmx），在上皮细胞的生长、分化、凋亡、增殖和致瘤性中起重要作用。本研究旨在探讨Etk/Bmx在肝内胆管癌（ICC）中的表达，并将其表达与临床病理参数相关联。
对57例ICC病例进行Etk/Bmx、HCV NS(5)、PCNA、bcl-2和NF-κB p65免疫染色。
57例ICC标本中有19例（33.3%）存在Etk/Bmx表达，其与细胞分化和生存率相关，但与肿瘤大小和淋巴结转移无密切关系。Etk/Bmx阳性和阴性病例之间PCNA-LI或Bcl-2的表达存在显著差异（P < 0.05）。然而，未发现Etk/Bmx表达与HCV-NS5或NF-κB p65的存在之间存在统计学上的显著关联。
我们的结果表明，Etk/Bmx可能参与ICC的发生发展，并且是ICC预后不良的一个预测指标。HCV感染和NF-κB似乎与Etk/Bmx表达无关。
