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心血管疾病中非受体酪氨酸激酶Tec家族的调控

Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease.

作者信息

Yin Zeyu, Zou Yuanming, Wang Dong, Huang Xinyue, Xiong Shengjun, Cao Liu, Zhang Ying, Sun Yingxian, Zhang Naijin

机构信息

Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, China.

Key Laboratory of Medical Cell Biology, Ministry of Education; Institute of Translational Medicine, China Medical University; Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, Shenyang, Liaoning, China.

出版信息

Cell Death Discov. 2022 Mar 16;8(1):119. doi: 10.1038/s41420-022-00927-4.

DOI:10.1038/s41420-022-00927-4
PMID:35296647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8927484/
Abstract

Tyrosine phosphorylation by protein tyrosine kinases (PTKs) is a type of post-translational modification. Tec kinases, which are a subfamily of non-receptor PTKs, were originally discovered in the hematopoietic system and include five members: Tec, Btk, Itk/Emt/Tsk, Etk/Bmx, and Txk/Rlk. With the progression of modern research, certain members of the Tec family of kinases have been found to be expressed outside the hematopoietic system and are involved in the development and progression of a variety of diseases. The role of Tec family kinases in cardiovascular disease is receiving increasing attention. Tec kinases are involved in the occurrence and progression of ischemic heart disease, atherosclerosis, cardiac dysfunction associated with sepsis, atrial fibrillation, myocardial hypertrophy, coronary atherosclerotic heart disease, and myocardial infarction and post-myocardial. However, no reviews have comprehensively clarified the role of Tec kinases in the cardiovascular system. Therefore, this review summarizes research on the role of Tec kinases in cardiovascular disease, providing new insights into the prevention and treatment of cardiovascular disease.

摘要

蛋白酪氨酸激酶（PTK）介导的酪氨酸磷酸化是一种翻译后修饰。Tec激酶是非受体PTK的一个亚家族，最初在造血系统中被发现，包括五个成员：Tec、Btk、Itk/Emt/Tsk、Etk/Bmx和Txk/Rlk。随着现代研究的进展，人们发现Tec激酶家族的某些成员在造血系统外表达，并参与多种疾病的发生和发展。Tec家族激酶在心血管疾病中的作用日益受到关注。Tec激酶参与缺血性心脏病、动脉粥样硬化、脓毒症相关的心功能障碍、心房颤动、心肌肥大、冠状动脉粥样硬化性心脏病、心肌梗死及心肌梗死后的发生和发展。然而，尚无综述全面阐明Tec激酶在心血管系统中的作用。因此，本综述总结了Tec激酶在心血管疾病中作用的研究，为心血管疾病的防治提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/7b60b25444af/41420_2022_927_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/4d0036d3f85b/41420_2022_927_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/45e96c3fb817/41420_2022_927_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/a92d5e7141cc/41420_2022_927_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/7b60b25444af/41420_2022_927_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/4d0036d3f85b/41420_2022_927_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/45e96c3fb817/41420_2022_927_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/a92d5e7141cc/41420_2022_927_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/8927484/7b60b25444af/41420_2022_927_Fig4_HTML.jpg

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