Mosca Paul J, Teicher Erik, Nair Suresh P, Pockaj Barbara A
Department of Surgery, Lehigh Valley Hospital, Allentown, PA, USA.
J Surg Oncol. 2008 Apr 1;97(5):462-8. doi: 10.1002/jso.20950.
Successful systemic management of stage IV melanoma continues to be elusive because of the paucity of effective therapies. This has fueled the continued interest in surgical resection. Several single-institution studies and a current, large, multi-institutional phase III trial have demonstrated a survival benefit for patients who underwent surgical resection for melanoma metastases. Incorporating these results into new approaches using multimodality treatment may enhance survival in patients with stage IV melanoma.
由于有效治疗方法匮乏，IV期黑色素瘤的成功系统管理仍然难以实现。这激发了人们对手术切除的持续兴趣。几项单机构研究以及一项当前的大型多机构III期试验表明，接受黑色素瘤转移灶手术切除的患者有生存获益。将这些结果纳入多模式治疗的新方法中，可能会提高IV期黑色素瘤患者的生存率。
