Lechtenberg M, Quandt B, Schmidt M, Nahrstedt A
Institute of Pharmaceutical Biology and Phytochemistry, Westfälische Wilhelms-Universität, Münster, Germany.
Pharmazie. 2008 Jan;63(1):71-4.
The pyridone alkaloid pipermethystine has been considered to be responsible for alleged hepatoxicity of Kava products. Investigation of a series of retain samples of finished products from the German market and self-produced extracts from root and stem material of Piper methysticum clearly showed that pipermethystine (1) is absent from all root and retain samples and extracts, with a limit of quantification of 45 ppm. As a positive control, leaves of P. methysticum showed an amount of 0.2% of 1. Thus, if there is any hepatotoxicity, compound 1 should not be the responsible constituent in the case reports with ethanolic extracts produced in Germany.
吡啶酮生物碱胡椒紫堇碱被认为是卡瓦产品所谓肝毒性的原因。对德国市场上一系列成品留存样品以及从卡瓦根和茎材料中自制提取物的调查清楚地表明，所有根、留存样品和提取物中均不存在胡椒紫堇碱（1），定量限为45 ppm。作为阳性对照，卡瓦叶中胡椒紫堇碱（1）的含量为0.2%。因此，如果存在任何肝毒性，在德国生产的乙醇提取物的病例报告中，化合物1不应是造成肝毒性的成分。
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