Rowe Anthony, Zhang Lillian Yuan, Ramzan Iqbal
Faculty of Pharmacy, University of Sydney, Bank Building (A15), Sydney, NSW 2006, Australia.
Adv Pharmacol Sci. 2011;2011:326724. doi: 10.1155/2011/326724. Epub 2011 Mar 21.
Kava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international reappraisal of its safety. Hepatotoxicity can occur as an acute, severe form or a chronic, mild form. Inflammation appears to be involved in both forms and may result from activation of liver macrophages (Kupffer cells), either directly or via kava metabolites. Pharmacogenomics may influence the severity of this inflammatory response.
卡瓦传统上被南太平洋岛民作为一种饮品饮用，并在西方社会作为治疗焦虑和失眠的补充剂而流行起来。卡瓦提取物一般耐受性良好，但肝毒性报告促使对其安全性进行国际重新评估。肝毒性可表现为急性、严重形式或慢性、轻度形式。炎症似乎在两种形式中都起作用，可能是由肝巨噬细胞（库普弗细胞）直接或通过卡瓦代谢物激活所致。药物基因组学可能会影响这种炎症反应的严重程度。
