Watanabe Hirokazu, Ishida Yusuke, Nagashima Kazuo, Makino Teruhiko, Norisugi Osamu, Shimizu Tadamichi
Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
J Dermatol. 2008 Feb;35(2):93-7. doi: 10.1111/j.1346-8138.2008.00421.x.
Desmoplastic fibroblastoma (DF) is a rare fibrotic tumor that has a wide anatomic distribution and it can appear in deep sections of the subcutis, in fascia, in aponeurosis or in skeletal muscles. This report describes a case of DF that appeared on the left side of the neck of a 55-year-old male as a 3.5-cm solitary, firm nodule. Histologically, it was composed of stellate or bland spindle-shaped cells embedded in a loose collagenous stroma. The entrapment of fat and muscle tissues was focally identified at the edges of the tumor. The stellate and multinucleated cells in the lesion were strongly positive for vimentin but negative for cytokeratin, smooth muscle actin, desmin, S-100, CD34, factor XIIIa, and CD68. These findings suggest that the stellate and multinucleated cells in the lesion were of fibroblastic origin and this neoplasm was pathologically benign.
促结缔组织增生性纤维母细胞瘤（DF）是一种罕见的纤维化肿瘤，其解剖分布广泛，可出现在皮下深层、筋膜、腱膜或骨骼肌中。本报告描述了一例发生在一名55岁男性颈部左侧的DF病例，表现为一个3.5厘米的孤立性、质地坚硬的结节。组织学上，它由嵌入疏松胶原基质中的星状或形态温和的梭形细胞组成。在肿瘤边缘局部可见脂肪和肌肉组织的包绕。病变中的星状细胞和多核细胞波形蛋白呈强阳性，但细胞角蛋白、平滑肌肌动蛋白、结蛋白、S-100、CD34、因子ⅩⅢa和CD68呈阴性。这些发现表明病变中的星状细胞和多核细胞起源于成纤维细胞，且该肿瘤在病理上为良性。
