Vanparijs O, Quick J M
Janssen Pharmaceutica NV, Beerse, Belgium.
Vet Parasitol. 1991 Jan;38(1):75-9. doi: 10.1016/0304-4017(91)90011-j.
The efficacy of levamisole pour-on against Dictyocaulus viviparus was compared to that of subcutaneous levamisole injection. Eighteen calves were raised individually and artifically infected with D. viviparus larvae. Faecal samples were collected 27 and 28 days later and larvae per gram (l.p.g.) determined. The animals were then divided into three comparable groups. Group 1 animals remained untreated as controls. Group 2 animals received levamisole 10% w/v subcutaneous injection at a dose of 5 mg kg-1 and Group 3 received levamisole pour-on 20% w/v at a rate of 10 mg kg-1 applied transdermally. Results of l.p.g. measurements from faecal samples taken 7 and 8 days post-treatment indicated a dramatic reduction in the worm burden of animals in both treatment groups. Necropsies at 14 days post-treatment revealed few adult worms in these groups, indicating a 99 and 98% kill rate for pouron and subcutaneous injection, respectively.
将左旋咪唑浇泼剂对胎生网尾线虫的疗效与皮下注射左旋咪唑的疗效进行了比较。18头犊牛单独饲养，并人工感染胎生网尾线虫幼虫。27天和28天后收集粪便样本，测定每克粪便中的幼虫数量（l.p.g.）。然后将这些动物分成三个可比组。第1组动物不接受治疗作为对照。第2组动物接受10% w/v左旋咪唑皮下注射，剂量为5 mg/kg-1，第3组接受20% w/v左旋咪唑浇泼剂，以10 mg/kg-1的剂量经皮给药。治疗后7天和8天采集的粪便样本中l.p.g.测量结果表明，两个治疗组动物体内的蠕虫负担显著降低。治疗后14天的尸检显示，这些组中几乎没有成虫，表明浇泼剂和皮下注射的杀灭率分别为99%和98%。
