Vercruysse J, Claerebout E, Dorny P, Demeulenaere D, Deroover E
Faculty of Veterinary Medicine, Department of Parasitology, Salisburylaan, Merelbeke, Belgium.
Vet Rec. 1997 Jan 18;140(3):64-6. doi: 10.1136/vr.140.3.64.
The persistence of the efficacy of moxidectin 0.5 per cent pour-on and moxidectin 1 per cent injectable against Ostertagia ostertagi and Dictyocaulus viviparus in calves was studied in two experimental trials. In the first trial two groups of seven calves were treated with either the pour-on or the injectable formulation, while a third group remained untreated. All the animals were infected daily from Monday to Friday with infective stages of O ostertagi and D viviparus between the day of treatment (day 0) and day 33, and were necropsied for worm counts three days later. The experimental design of the second trial was similar to that of the first but the period of infection was from 28 to 45 days after the treatment, and the necropsy was five days after the last infection. In both trials both moxidectin formulations had very high efficacies (99.6 per cent) against adult and developing stages of O ostertagi and D viviparus. The higher efficacy of the moxidectin pour-on preparation against early fourth stage larvae in both trials suggested that its effect was more persistent. It was calculated that the efficacy of moxidectin against O ostertagi persisted for at least five weeks for the injectable formulation and six weeks for the pour-on. The efficacy of moxidectin against D viviparus lasted for at least six weeks for both formulations.
在两项试验中研究了0.5%莫昔克丁浇泼剂和1%莫昔克丁注射液对犊牛奥斯特他线虫和胎生网尾线虫的持续疗效。在第一项试验中，两组各7头犊牛分别用浇泼剂或注射液进行治疗，第三组不治疗。从治疗当天（第0天）到第33天，所有动物从周一至周五每天感染奥斯特他线虫和胎生网尾线虫的感染阶段，3天后进行剖检以计数蠕虫。第二项试验的设计与第一项类似，但感染期为治疗后28至45天，剖检在最后一次感染后5天进行。在两项试验中，两种莫昔克丁制剂对奥斯特他线虫和胎生网尾线虫的成虫及发育阶段均有很高的疗效（99.6%）。在两项试验中，莫昔克丁浇泼剂对第四期早期幼虫的疗效更高，表明其效果更持久。据计算，莫昔克丁注射液对奥斯特他线虫的疗效至少持续5周，浇泼剂持续6周。两种制剂对胎生网尾线虫的疗效均至少持续6周。
