Lock Edward A, Bonventre Joseph V
School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK.
Toxicology. 2008 Mar 20;245(3):163-6. doi: 10.1016/j.tox.2007.12.004. Epub 2007 Dec 17.
The search for biomarkers and their evaluation by scientists and clinicians is of paramount importance if we are going to improve health care. In this paper we discuss the history of the discovery of biomarkers for renal and cardiac injury. We also summarize the use of biomarkers in preclinical evaluation in experimental animals and in patients to help diagnose or monitor a disease, predict outcome or to evaluate a therapeutic intervention. The need for validated biomarkers of tissue injury or disease that must be easy to analyse rapidly, preferably at the bedside, is essential if clinical decision making is to be optimally affected by their use.
如果我们想要改善医疗保健，科学家和临床医生对生物标志物的寻找及其评估至关重要。在本文中，我们讨论了肾脏和心脏损伤生物标志物的发现历史。我们还总结了生物标志物在实验动物和患者的临床前评估中的应用，以帮助诊断或监测疾病、预测预后或评估治疗干预。如果临床决策要受到它们的使用的最佳影响，那么就必须有经过验证的、易于快速分析（最好是在床边）的组织损伤或疾病生物标志物。
