垂体腺苷酸环化酶激活多肽（PACAP）1型受体（PAC1-R）酰肼类拮抗剂的发现与构效关系研究
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R).
作者信息
Beebe Xenia, Darczak Daria, Davis-Taber Rachel A, Uchic Marie E, Scott Victoria E, Jarvis Michael F, Stewart Andrew O
机构信息
Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-1066, USA.
出版信息
Bioorg Med Chem Lett. 2008 Mar 15;18(6):2162-6. doi: 10.1016/j.bmcl.2008.01.052. Epub 2008 Jan 18.
PMID:18272364
Abstract
Potent small molecule antagonists for the PAC(1)-R have been discovered. Previously known antagonists for the PAC(1)-R were slightly truncated peptide ligands. The hydrazides reported here are the first small molecule antagonists ever reported for this class B GPCR.
摘要
已发现针对PAC(1)-R的强效小分子拮抗剂。此前已知的PAC(1)-R拮抗剂是略有截短的肽配体。本文报道的酰肼是首次报道的针对这类B类GPCR的小分子拮抗剂。
Zotero 插件