星形孢菌素既能激活又能抑制人血小板中的丝氨酸/苏氨酸激酶。
Staurosporine both activates and inhibits serine/threonine kinases in human platelets.
作者信息
Kocher M, Clemetson K J
机构信息
Theodor Kocher Institute, University of Berne, Switzerland.
出版信息
Biochem J. 1991 Apr 15;275 ( Pt 2)(Pt 2):301-6. doi: 10.1042/bj2750301.
Abstract
The effects of staurosporine on a selection of protein kinases were investigated with thrombin-stimulated and control human blood platelets. The results demonstrate that staurosporine (1 microM) can lead to activation of certain protein kinases in intact platelets and has a general inhibitory effect on the renaturable protein kinases in vitro. New candidates for protein kinases involved in signal transduction are identified.
摘要
用凝血酶刺激的和未刺激的人血小板研究了星形孢菌素对一系列蛋白激酶的作用。结果表明，星形孢菌素（1微摩尔）可导致完整血小板中某些蛋白激酶的激活，并在体外对可复性蛋白激酶具有普遍抑制作用。确定了参与信号转导的蛋白激酶的新候选者。
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