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Staurosporine both activates and inhibits serine/threonine kinases in human platelets.
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2
Serine/threonine kinases in signal transduction in response to thrombin in human platelets. Use of 17-hydroxywortmannin to discriminate signals.
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3
Effects of 17-hydroxywortmannin on serine/threonine-protein kinases in human blood platelets.
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Activation of a serine/threonine kinase signaling pathway by transforming growth factor type beta.
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Phosphorylation of JAK2 in thrombin-stimulated human platelets.
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Thrombin stimulates the activities of multiple previously unidentified protein kinases in platelets.
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7
The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin.
Biochem J. 1988 Jan 15;249(2):345-50. doi: 10.1042/bj2490345.
8
Agonist-induced ADP-ribosylation of a cytosolic protein in human platelets.
Proc Natl Acad Sci U S A. 1990 May;87(9):3304-8. doi: 10.1073/pnas.87.9.3304.
9
Thrombin-induced activation of the novel 33-kDa serine/threonine kinase in human platelets.
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Thrombin- and cathepsin G-induced platelet aggregation: effect of protein kinase C inhibitors.
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引用本文的文献
1
Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets.
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2
Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by Munc-18.
Neurochem Res. 1996 May;21(5):629-36. doi: 10.1007/BF02527763.
3
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid.
Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):849-56. doi: 10.1042/bj2900849.
4
The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.
Mol Neurobiol. 1991;5(2-4):87-130. doi: 10.1007/BF02935541.
5
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
Biochem J. 1992 Dec 15;288 ( Pt 3)(Pt 3):853-8. doi: 10.1042/bj2880853.
6
Activation of protein kinase C is not an absolute requirement for amylase release from permeabilized rat pancreatic acini.
Biochem J. 1992 Jul 15;285 ( Pt 2)(Pt 2):597-601. doi: 10.1042/bj2850597.
7
Apical and basolateral Na/H exchange in cultured murine proximal tubule cells (MCT): effect of parathyroid hormone (PTH).
J Membr Biol. 1992 Dec;130(3):205-17. doi: 10.1007/BF00240478.
本文引用的文献
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Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains.
Nature. 1983;306(5942):490-2. doi: 10.1038/306490a0.
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Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.
J Biol Chem. 1983 Jun 10;258(11):6701-4.
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The role of protein kinase C in cell surface signal transduction and tumour promotion.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
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A yeast gene that is essential for release from glucose repression encodes a protein kinase.
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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
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The protein kinase inhibitor staurosporine, like phorbol esters, induces the association of protein kinase C with membranes.
Biochem Biophys Res Commun. 1988 Aug 15;154(3):1273-9. doi: 10.1016/0006-291x(88)90277-x.
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Monoclonal antibody recognition of two subtype forms of protein kinase C in human platelets.
Biochem Biophys Res Commun. 1988 Apr 29;152(2):642-8. doi: 10.1016/s0006-291x(88)80087-1.
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The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin.
Biochem J. 1988 Jan 15;249(2):345-50. doi: 10.1042/bj2490345.
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Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action.
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