Hughes L M, Bao J, Hu Z-L, Honavar V, Reecy J M
Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, 2255 Kildee Hall, Ames 50011, USA.
J Anim Sci. 2008 Jun;86(6):1485-91. doi: 10.2527/jas.2008-0930. Epub 2008 Feb 13.
Ontologies help to identify and formally define the entities and relationships in specific domains of interest. Bio-ontologies, in particular, play a central role in the annotation, integration, analysis, and interpretation of biological data. Missing from the number of bio-ontologies is one that includes phenotypic trait information found in livestock species. As a result, the Animal Trait Ontology (ATO) project being carried out under the auspices of the USDA-National Animal Genome Research Program is aimed at the development of a standardized trait ontology for farm animals and software tools to assist the research community in collaborative creation, editing, maintenance, and use of such an ontology. The ATO is currently inclusive of cattle, pig, and chicken species, and will include other livestock species in the future. The ATO will eventually be linked to other species (e.g., human, rat, mouse) so that comparative analysis can be efficiently performed between species.
本体有助于识别并正式定义特定感兴趣领域中的实体和关系。特别是生物本体,在生物数据的注释、整合、分析和解释中发挥着核心作用。生物本体的数量中缺少一个包含家畜物种表型特征信息的本体。因此,在美国农业部国家动物基因组研究计划的支持下开展的动物性状本体(ATO)项目,旨在开发一种用于农场动物的标准化性状本体以及软件工具,以协助研究团体协作创建、编辑、维护和使用这样的本体。ATO目前涵盖牛、猪和鸡等物种,未来还将包括其他家畜物种。ATO最终将与其他物种(如人类、大鼠、小鼠)相链接,以便能够在物种之间高效地进行比较分析。