Genome Dynamics Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Genome Biol. 2010 Jan 8;11(1):R2. doi: 10.1186/gb-2010-11-1-r2.
Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.
表型本体通常是为满足特定社区的需求而构建的，例如在小鼠或人类中注释基因型-表型关联。在这里，我们展示了如何通过使用表型质量的核心本体和来自开放生物学本体库的多个其他本体来分配逻辑定义来改进这些本体。我们还展示了当与统一的多物种解剖学本体结合使用时，这些逻辑定义如何用于数据集成。
