乳腺癌与家族性恶性肿瘤之间的关联。

Association between breast cancer and family malignancies.

作者信息

Andrieu N, Clavel F, Auquier A, Gairard B, Brémond A, Lansac J, Piana L, Flamant R, Renaud R

机构信息

Unité de Recherche en Epidémiologie des Cancers, Institut Gustave Roussy, Villejuif, France.

出版信息

Eur J Cancer. 1991;27(3):244-8. doi: 10.1016/0277-5379(91)90506-9.

DOI:10.1016/0277-5379(91)90506-9

PMID:1827304

Abstract

In a case-control study, the relationship between a family history of cancer of the breast, ovary, colon, uterus or prostate and the risk of breast cancer was investigated. The data consisted of family histories from 495 breast cancer cases and 785 controls aged 20-56 years. A positive association was found between the occurrence of breast cancer and a history of breast cancer in the families of the subjects affected. This relationship increased linearly with both the degree of kinship of the affected relatives and with their number. The risk of breast cancer associated with other types of cancer in the family was not significantly different from unity.

摘要

在一项病例对照研究中，对乳腺癌、卵巢癌、结肠癌、子宫癌或前列腺癌家族史与乳腺癌风险之间的关系进行了调查。数据包括495例20 - 56岁乳腺癌病例和785例对照的家族史。在受影响受试者的家族中，乳腺癌的发生与乳腺癌家族史之间存在正相关。这种关系随着受影响亲属的亲属关系程度及其数量呈线性增加。家族中与其他类型癌症相关的乳腺癌风险与1无显著差异。