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[老年机构中的抗精神病药物]

[Antipsychotics in geriatric institutions].

作者信息

Szulik Judith

机构信息

Nuevo Hogar LeDor Vador, Asociación Latinoamericana de Psicogeriatría.

出版信息

Vertex. 2007 Nov-Dec;18(76):454-60.

Abstract

The present paper approaches the use of antipsychotics in elder people in general, and particularly in geriatric institutions. During the last few years, prescription of antipsychotics in geriatric institutions increased, especially because of the availability of the atypicals, and their use was extended beyond the indications these drugs had been approved for. In dementia they are suggested for treatment of behavioral symptoms, despite having been approved only for cases of aggressiveness and risk of damage. There is a common tendency of perpetuating antipsychotic medication in elder people, with its consequent collateral effects as well. Few years ago, the increase of both risk of cerebrovascular events and of mortality in dementia patients treated with atypical agents was noticed. This generated controversy regarding their use in those kind of patients. Diverse factors associated to caregivers affect the decision of prescribing an antipsychotic in elder people. Non-pharmacological interventions are the first choice when treating behavioral symptoms; pharmacological interventions must take place with the lowest doses possible, with limited durations.

摘要

本文探讨了抗精神病药物在老年人中的使用情况,特别是在老年机构中的使用。在过去几年中,老年机构中抗精神病药物的处方量有所增加,尤其是由于非典型抗精神病药物的可获得性,并且其使用范围超出了这些药物已获批的适应症。在痴呆症患者中,尽管这些药物仅被批准用于攻击性和损伤风险情况,但仍被建议用于治疗行为症状。在老年人中,存在持续使用抗精神病药物的普遍趋势,随之而来的还有其附带影响。几年前,人们注意到使用非典型药物治疗的痴呆症患者脑血管事件风险和死亡率均有所增加。这引发了关于在这类患者中使用这些药物的争议。与护理人员相关的多种因素会影响为老年人开具抗精神病药物的决定。在治疗行为症状时,非药物干预是首选;药物干预必须尽可能采用最低剂量,并限制用药时间。

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